One has to remember that the Panzerbox does not have a great deal of room to work once the motherboard is installed, but since the case has a removable motherboard tray it is not that big of a deal. There are a few places to re-route wires and cables, but if attention is paid it can be done with to much work.
Since the Panzerbox is able to support the longest video cards the hard drive arrangement had to be setup specially. Here you can see the dual hard drive mount that is directly behind 190mm fan. Directly above it is the only other 3.5" hard drive trays. I would think if you filled the case with four 1-TB drives you would have enough space.
Up next is the three 3.25" drive bays, these bays use the good old tried and trusted screws to attach the drives to the cage. there is nothing really tool-free about this case and I really don't have any problems with this design.
Here you can see the 190mm fan located at the top of the case, since the Panzebox does not make use of any type of filtering on all of the large drive one might wanted to place something like a dryer fabric behind the fans to help filter the dirt and dust out of the caqse.
The slot covers on the Panzerbox are all held in place by knurled thumbscrews and each of the slot covers have additional air passages thru them for better air movement.